T-cell recognition of myelin basic protein
- PMID: 1716903
- DOI: 10.1016/0167-5699(91)90126-E
T-cell recognition of myelin basic protein
Abstract
Multiple sclerosis is a chronic inflammatory disease of the central nervous system which has been hypothesized to be autoimmune in nature. To test whether this is the case, Kai Wucherpfennig and colleagues have developed a set of criteria that must be met to satisfy the hypothesis. Here, they present these criteria and assess the extent to which studies to date satisfy them.
Comment in
-
Viral homologies with myelin basic protein.Immunol Today. 1991 Dec;12(12):464-5. doi: 10.1016/0167-5699(91)90022-L. Immunol Today. 1991. PMID: 1723879 No abstract available.
Similar articles
-
Autoreactive T cells in multiple sclerosis.Int Rev Immunol. 1992;9(3):183-201. doi: 10.3109/08830189209061790. Int Rev Immunol. 1992. PMID: 1285060 Review. No abstract available.
-
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.Nature. 1990 Jul 12;346(6280):183-7. doi: 10.1038/346183a0. Nature. 1990. PMID: 1694970
-
[Therapeutic immunomodulation in neurology: from hope to reality. Exemplified by multiple sclerosis].Praxis (Bern 1994). 1995 Sep 19;84(38):1021-4. Praxis (Bern 1994). 1995. PMID: 7481299 French.
-
Immunopathogenic mechanisms in experimental allergic encephalomyelitis.Curr Opin Neurol Neurosurg. 1993 Apr;6(2):182-8. Curr Opin Neurol Neurosurg. 1993. PMID: 7683223 Review.
-
A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor.Nat Genet. 1999 Nov;23(3):343-7. doi: 10.1038/15525. Nat Genet. 1999. PMID: 10610182
Cited by
-
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.J Clin Invest. 1997 Sep 1;100(5):1114-22. doi: 10.1172/JCI119622. J Clin Invest. 1997. PMID: 9276728 Free PMC article.
-
Circulating antibodies to lung protein(s) in patients with cryptogenic fibrosing alveolitis.Thorax. 1994 Mar;49(3):218-24. doi: 10.1136/thx.49.3.218. Thorax. 1994. PMID: 8202877 Free PMC article.
-
In Silico Perspectives on the Prediction of the PLP's Epitopes involved in Multiple Sclerosis.Iran J Biotechnol. 2017 Mar;15(1):10-21. doi: 10.15171/ijb.1356. Iran J Biotechnol. 2017. PMID: 28959348 Free PMC article.
-
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker.Basic Clin Neurosci. 2021 May-Jun;12(3):309-314. doi: 10.32598/bcn.2021.950.2. Epub 2021 May 1. Basic Clin Neurosci. 2021. PMID: 34917290 Free PMC article.
-
Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability.Dig Dis Sci. 1996 Dec;41(12):2493-8. doi: 10.1007/BF02100148. Dig Dis Sci. 1996. PMID: 9011463 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous