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Clinical Trial
. 1991;27(8):954-8.
doi: 10.1016/0277-5379(91)90257-e.

A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone

V J Lewington  1 , A J McEwan, D M Ackery, R J Bayly, D H Keeling, P M Macleod, A T Porter, M A Zivanovic
Affiliations
Clinical Trial

A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone

V J Lewington et al. Eur J Cancer. 1991.

Abstract

The palliative efficacy of strontium-89 chloride has been evaluated in a prospective double-blind crossover study comparing it with stable strontium as placebo in 32 patients with prostate cancer metastatic to bone. Response was assessed 5 weeks after each treatment. 26 patients were evaluable. Complete pain relief was only reported following strontium-89 injection. Statistical comparison between placebo and strontium-89 showed clear evidence of a therapeutic response to strontium-89 compared with only a limited placebo effect (P less than 0.01).

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