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Comment
. 2007 Jan;127(1):6-8.
doi: 10.1038/sj.jid.5700604.

IL-6 signaling pathway in keloids: a target for pharmacologic intervention?

Jouni Uitto  1
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IL-6 signaling pathway in keloids: a target for pharmacologic intervention?

Jouni Uitto. J Invest Dermatol. 2007 Jan.
Free article

Abstract

Keloids are cosmetically devastating lesions with considerable morbidity. Ghazizadeh et al. document enhanced expression of IL-6 and its receptors in keloid fibroblasts, with a concomitant increase in collagen biosynthesis. Anti-IL-6 antibodies or blocking the IL-6 receptors elicits reduced collagen synthesis, suggesting a role for IL-6 in the regulation of collagen gene expression. These observations imply the feasibility of a pharmacologic platform, based on the targeting of the IL-6 signaling pathway, in keloids.

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