Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1999;9(1):51-6.
doi: 10.1055/s-2008-1058173.

Multifocal langerhans' cell histiocytosis involving bilateral temporal bones, lungs, and hypothalamus in an adult

E G Whitaker, D Cerenko, S Muller, P Hudgins
Case Reports

Multifocal langerhans' cell histiocytosis involving bilateral temporal bones, lungs, and hypothalamus in an adult

E G Whitaker et al. Skull Base Surg. 1999.

Abstract

Multifocal Langerhans' cell histocytosis is a rare condition in adults. We present the case of a 31-year-old female who initially presented with a clinical appearance of acute mastoiditis. The patient ultimately had involvement of bilateral temporal bones, lungs, and hypothalamus. Treatment with methotrexate, steroids, and desmopressin acetate (DDAVP) resulted in initial clinical improvement though not resolution. The patient also underwent radiation therapy to the hypothalamic lesion. The literature is reviewed, focusing on the diagnostic challenge of this disease process in adults. The additional morbidity of surgery, specifically mastoidectomy, in the setting of Langerhan's cell histiocytosis is discussed.

PubMed Disclaimer

References

    1. Otolaryngol Head Neck Surg (1979). 1980 Sep-Oct;88(5):544-7 - PubMed
    1. Laryngoscope. 1973 Jun;83(6):877-89 - PubMed
    1. Medicine (Baltimore). 1981 Sep;60(5):311-38 - PubMed
    1. Am J Surg Pathol. 1982 Jul;6(5):413-26 - PubMed
    1. Arch Otolaryngol. 1980 Mar;106(3):167-71 - PubMed

Publication types