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. 2006 Dec 21;12(47):7699-704.
doi: 10.3748/wjg.v12.i47.7699.

Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy

Ying-Mei Zhang  1 , Xiu-Li Liu, Dong-Bo Xue, Yun-Wei Wei, Xiao-Guang Yun
Affiliations

Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy

Ying-Mei Zhang et al. World J Gastroenterol. .

Abstract

Aim: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.

Methods: The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.

Results: When compared with the cut group, the amplitude (1.15 +/- 0.15 mV vs 0.48 +/- 0.06 mV, P < 0.05) and frequency (14.4 +/- 1.9 cpm vs 9.5 +/- 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% +/- 10.4% vs 56.6% +/- 6.4%, P < 0.05) and amplitude (0.58 +/- 0.08 mV vs 0.23 +/- 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase III duration in the uncut group was significantly prolonged (6.5 +/- 1.1 min vs 4.4 +/- 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 +/- 6.8 vs 55.3 +/- 8.2 min, P < 0.05). Both gastric emptying rate (65.5% +/- 7.9% vs 49.3% +/- 6.8%, P < 0.01) and intestinal impelling ratio (53.4% +/- 7.4% vs 32.2% +/- 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 +/- 5.1 vs 15.3 +/- 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 +/- 0.11 vs 0.35 +/- 0.06, P < 0.01).

Conclusion: Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.

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Figures

Figure 1
Figure 1
Distal gastrectomy, cut or uncut Roux-en-Y gastrojejunostomy, placement of electrodes.
Figure 2
Figure 2
Original manometric tracings showing the myoelectric activity of the Roux limb.
Figure 3
Figure 3
Diagram of MMC of the Roux limb.
Figure 4
Figure 4
Motility of isolated jejunal segment.
Figure 5
Figure 5
Expression of c-kit mRNA in jejunal segment. L1: Cut group; L2: Uncut group; M: DL-2000 molecular weight markers.
See this image and copyright information in PMC

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