Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Dec 21;12(47):7699-704.
doi: 10.3748/wjg.v12.i47.7699.

Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy

Ying-Mei Zhang  1 , Xiu-Li Liu, Dong-Bo Xue, Yun-Wei Wei, Xiao-Guang Yun
Affiliations

Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy

Ying-Mei Zhang et al. World J Gastroenterol. .

Abstract

Aim: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.

Methods: The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.

Results: When compared with the cut group, the amplitude (1.15 +/- 0.15 mV vs 0.48 +/- 0.06 mV, P < 0.05) and frequency (14.4 +/- 1.9 cpm vs 9.5 +/- 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% +/- 10.4% vs 56.6% +/- 6.4%, P < 0.05) and amplitude (0.58 +/- 0.08 mV vs 0.23 +/- 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase III duration in the uncut group was significantly prolonged (6.5 +/- 1.1 min vs 4.4 +/- 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 +/- 6.8 vs 55.3 +/- 8.2 min, P < 0.05). Both gastric emptying rate (65.5% +/- 7.9% vs 49.3% +/- 6.8%, P < 0.01) and intestinal impelling ratio (53.4% +/- 7.4% vs 32.2% +/- 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 +/- 5.1 vs 15.3 +/- 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 +/- 0.11 vs 0.35 +/- 0.06, P < 0.01).

Conclusion: Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distal gastrectomy, cut or uncut Roux-en-Y gastrojejunostomy, placement of electrodes.
Figure 2
Figure 2
Original manometric tracings showing the myoelectric activity of the Roux limb.
Figure 3
Figure 3
Diagram of MMC of the Roux limb.
Figure 4
Figure 4
Motility of isolated jejunal segment.
Figure 5
Figure 5
Expression of c-kit mRNA in jejunal segment. L1: Cut group; L2: Uncut group; M: DL-2000 molecular weight markers.
See this image and copyright information in PMC

References

    1. Eagon JC, Miedema BW, Kelly KA. Postgastrectomy syndromes. Surg Clin North Am. 1992;72:445–465. - PubMed
    1. Qin XY, Lei Y, Liu FL. Effects of two methods of reconstruction of digestive tract after total gastrectomy on gastrointestinal motility in rats. World J Gastroenterol. 2003;9:1051–1053. - PMC - PubMed
    1. Zonca S, Rizzo P. Alteration of the Roux Stasis syndrome by an isolated Roux limb: correlation of slow waves and clinical course. Am Surg. 1999;65:666–672. - PubMed
    1. Kummer EW, Gerritsen JJ, Brummelkamp WH. The cut-closed-reconnected Roux loop. Am J Surg. 2000;179:141–144. - PubMed
    1. Tu BL, Kelly KA. Surgical treatment of Roux stasis syndrome. J Gastrointest Surg. 1999;3:613–617. - PubMed

MeSH terms