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Case Reports
. 2007 Mar-Apr;42(2):158-60.
doi: 10.1093/alcalc/agl091. Epub 2006 Dec 15.

Suppression of symptoms of alcohol dependence and craving using high-dose baclofen

William Bucknam  1
Affiliations
Case Reports

Suppression of symptoms of alcohol dependence and craving using high-dose baclofen

William Bucknam. Alcohol Alcohol. 2007 Mar-Apr.

Abstract

Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans.

Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day.

Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol.

Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.

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