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. 2006 Dec;3(4):447-57.
doi: 10.1093/ecam/nel075. Epub 2006 Oct 27.

DNA microarrays in herbal drug research

Preeti Chavan, Kalpana Joshi, Bhushan Patwardhan

DNA microarrays in herbal drug research

Preeti Chavan et al. Evid Based Complement Alternat Med. 2006 Dec.

Abstract

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.

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Figures

Figure 1
Figure 1
DNA microarray: applications in natural product drug discovery and development.
Figure 2
Figure 2
Microarray-based gene expression analysis of multi-component mixtures.
See this image and copyright information in PMC

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