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Comment
. 2006 Dec 16;368(9553):2110-1.
doi: 10.1016/S0140-6736(06)69843-7.

Pralidoxime for organophosphate poisoning

Peter Eyer  1 , Nicholas Buckley
Affiliations
Comment

Pralidoxime for organophosphate poisoning

Peter Eyer et al. Lancet. .
No abstract available

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Figures

Figure
Figure
Calculated pralidoxime plasma concentration, two-dose regimen Calculated for 50-kg person. High dose=2-g bolus over 30 min, then continuous infusion of 1 g/h for 48 h, then 1 g/h every 4 h. Low dose=2-g bolus over 30 min, then 1 g/h every 4 h.
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References

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    1. Eyer P. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicol Rev. 2003;22:165–190. - PubMed
    1. Johnson MK, Jacobsen D, Meredith TJ. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg Med. 2000;12:22–37.
    1. Eddleston M, Eyer P, Worek F. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet. 2005;366:1452–1459. - PubMed
    1. European Association of Poisons Centres and Clinical Toxicologists/American Academy of Clinical Toxicology Position paper: ipecac syrup. J Toxicol Clin Toxicol. 2004;42:133–143.

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