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Comment
. 2006 Dec 15;127(6):1091-3.
doi: 10.1016/j.cell.2006.11.034.

In vino veritas: a tale of two sirt1s?

Seung-Hoi Koo  1 , Marc Montminy
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In vino veritas: a tale of two sirt1s?

Seung-Hoi Koo et al. Cell. .
Free article

Abstract

Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.

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