Sensory neurons link the nervous system and autoimmune diabetes
- PMID: 17174888
- DOI: 10.1016/j.cell.2006.11.030
Sensory neurons link the nervous system and autoimmune diabetes
Abstract
The initial factors that trigger the autoimmune response against pancreatic islets in the nonobese diabetic (NOD) mouse are still unknown. In this issue of Cell, propose that a defect in a subset of sensory neurons innervating the pancreas plays a major role in initiating the chain of events that will lead to local inflammation, islet destruction, and autoimmune diabetes.
Comment on
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TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.Cell. 2006 Dec 15;127(6):1123-35. doi: 10.1016/j.cell.2006.10.038. Cell. 2006. PMID: 17174891
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