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Comment
. 2006 Dec 19;16(24):R1030-2.
doi: 10.1016/j.cub.2006.11.011.

Chemotaxis: Cofilin in the driver's seat

Sarah E Hitchcock-Degregori  1
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Chemotaxis: Cofilin in the driver's seat

Sarah E Hitchcock-Degregori. Curr Biol. .
Free article

Abstract

A cell responds to a chemotactic signal by activating actin polymerization and forming a protrusion oriented towards the source. Recent work shows that the activity of cofilin, a protein that creates new barbed ends for actin filament elongation, amplifies and specifies the direction of the response in carcinoma cells.

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