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Review
. 2007 Jan;1773(1):2-7.
doi: 10.1016/j.bbamcr.2006.09.019. Epub 2006 Sep 19.

p120-catenin: Past and present

Albert B Reynolds  1
Affiliations
Review

p120-catenin: Past and present

Albert B Reynolds. Biochim Biophys Acta. 2007 Jan.

Abstract

p120-catenin was first described in 1989 as a Src substrate whose phosphorylation correlated with transformation. It was identified by cDNA cloning in 1992, and shown to interact with cadherins in 1994. Though enigmatic for some time, p120 has emerged as a master regulator of cadherin stability, and an important modulator of RhoGTPase activities. With the discovery of p120 family members and evidence for fundamental roles in cell biology and cancer, the field has expanded dramatically in recent years. As an introduction to this collection of reviews on p120 and its relatives, the editors have requested a personal commentary and historical perspective on the discovery of p120. The anecdotal parts have no particular purpose, but are mostly unpublished and perhaps of interest to some.

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References

    1. Reynolds AB, Roesel DJ, Kanner SB, Parsons JT. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol. 1989;9:629–638. - PMC - PubMed
    1. Reynolds AB, Herbert L, Cleveland JL, Berg ST, Gaut JR. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992;7:2439–45. - PubMed
    1. Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu J, Zhang Z. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol. 1994;14:8333–42. - PMC - PubMed
    1. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M, et al. Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes. J Cell Biol. 1995;128:949–57. - PMC - PubMed
    1. Ireton R, Davis M, van Hengel J, Mariner D, Barnes K, Thoreson M, Anastasiadis P, Matrisian L, Bundy L, Sealy L, Gilbert B, van Roy F, Reynolds A. A novel role for p120 catenin in E-cadherin function. The Journal of Cell Biology. 2002;159:465–476. - PMC - PubMed