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Review
. 2006 Dec;39(12):918-24.
doi: 10.1021/ar040020w.

Reversible binding of heme to proteins in cellular signal transduction

Shangwei Hou  1 , Mark F Reynolds, Frank T Horrigan, Stefan H Heinemann, Toshinori Hoshi
Affiliations
Review

Reversible binding of heme to proteins in cellular signal transduction

Shangwei Hou et al. Acc Chem Res. 2006 Dec.

Abstract

Heme plays critical roles in numerous biological phenomena. Recent evidence has uncovered a new role of heme in cellular signal transduction, and its mechanism involves reversible binding of heme to proteins. This Account highlights the novel function of heme as an intracellular messenger in the regulation of gene expression and ion channel function.

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