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Case Reports
. 2006 Oct;12(10):1572-5.
doi: 10.3201/eid1210.051647.

Fourth human parechovirus serotype

Kimberley S M Benschop  1 , Janke Schinkel, Manon E Luken, Peter J M van den Broek, Matthias F C Beersma, Negassi Menelik, Hetty W M van Eijk, Hans L Zaaijer, Christina M J E VandenBroucke-Grauls, Marcel G H M Beld, Katja C Wolthers
Affiliations
Case Reports

Fourth human parechovirus serotype

Kimberley S M Benschop et al. Emerg Infect Dis. 2006 Oct.

Abstract

We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.

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Figures

Figure 1
Figure 1
Unrooted phylogenetic trees showing the relationship between K251176-02 (DQ315670) and the prototype strains human parechovirus serotype 1 (HPeV1) Harris (S45208), HPeV2 Williamson (AJ005695), HPeV2 CT86-6760 (AF055846), HPeV3 A308-99 (AB084913), and Can82853-01 (AJ889918) based on nucleotide Jukes and Cantor substitution model for the capsid region (A) and the nonstructural region (B). The tree was constructed by the neighbor-joining method as implemented in MEGA version 3.1. Gaps introduced for optimal alignment were not considered informative and were excluded from the analyses by complete deletion. Numbers represent the frequency of occurrence of nodes in 1,000 bootstrap replicas. The use of other evolution models did not influence the tree topology.
Figure 2
Figure 2
Similarity plot of human parechovirus serotype 1 (HPeV1) Harris (S45208), HPeV2 Williamson (AJ005695), HPeV2 CT86-6760 (AF055846), HPeV3 A308-99 (AB084913), and Can82853-01 (AJ889918) against K251176-02. Each curve is a comparison between the K251176-02 genome and an HPeV prototype. Each point represents the percentage identity within a sliding window 600 bp wide, centered on the position plotted, with a step size of 20 bp. Positions containing gaps were excluded from the comparison by gap stripping, and Jukes and Cantor correction was applied. Similarity plots of the full-length sequences of the HPeV prototypes were generated by using SimPlot version 2.5.
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