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. 2006 Oct;12(10):1596-9.
doi: 10.3201/eid1210.060078.

Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa

Zhiquan Xiang  1 , Yan Li, Ann Cun, Wei Yang, Susan Ellenberg, William M Switzer, Marcia L Kalish, Hildegund C J Ertl
Affiliations

Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa

Zhiquan Xiang et al. Emerg Infect Dis. 2006 Oct.

Abstract

Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses. Antibodies were more common in humans residing in sub-Saharan Africa than in humans living in the United States or Thailand. This finding suggests cross-species transmission of chimpanzee adenoviruses.

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Figures

Figure
Figure
Prevalence of neutralizing antibody titers to chimpanzee adenoviruses. Percentages of negative samples are not shown. Left column: Cameroon, black bars; Côte d'Ivoire, white bars; Nigeria: gray bars. Middle column: Thailand, black bars; US controls, white bars; US zoo keepers or animal handlers, gray bars. VNAs, virus neutralizing antibodies. Coded human serum samples that had been collected for other studies were obtained under an institutional review board exemption.
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References

    1. Xiang ZQ, Yang Y, Wilson JM, Ertl HC. A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. Virology. 1996;219:220–7. 10.1006/viro.1996.0239 - DOI - PubMed
    1. Shiver JW, Fu TM, Chen L, Casimiro DR, Davies ME, Evans RK, et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature. 2002;415:331–5. 10.1038/415331a - DOI - PubMed
    1. Vinner L, Wee EG, Patel S, Corbet S, Gao GP, Nielsen C, et al. Immunogenicity in Mamu-A*01 rhesus macaques of a CCR5-tropic human immunodeficiency virus type 1 envelope from the primary isolate (Bx08) after synthetic DNA prime and recombinant adenovirus 5 boost. J Gen Virol. 2003;84:203–13. 10.1099/vir.0.18589-0 - DOI - PubMed
    1. Fitzgerald JC, Gao GP, Reyes-Sandoval A, Pavlakis GN, Xiang ZQ, Wlazlo AP, et al. A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag. J Immunol. 2003;170:1416–22. - PubMed
    1. Casimiro DR, Chen L, Fu TM, Evans RK, Caulfield MJ, Davies ME, et al. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol. 2003;77:6305–13. 10.1128/JVI.77.11.6305-6313.2003 - DOI - PMC - PubMed

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