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. 1975 Nov 14;190(4215):682-4.
doi: 10.1126/science.171768.

In vitro demonstration of an endothelial proliferative factor produced by neural cell lines

R L Suddith, P J Kelly, H T Hutchison, E A Murray, B Haber

In vitro demonstration of an endothelial proliferative factor produced by neural cell lines

R L Suddith et al. Science. .

Abstract

Cultured endothelial cells exhibit a six- to tenfold increase in thymidine labeling index in response to a soluble factor elaborated by clonal cell lines of neural origin. This factor, endothelial proliferation factor, appears to be a unique property of tumor cells and may mediate the vascularization of these neoplasms.

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