Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Winter;53(4):119-25.
doi: 10.2344/0003-3006(2006)53[119:CEOF]2.0.CO;2.

Cardiovascular effects of felypressin

Rodrigo Cecanho  1 , Laurival Antonio De Luca Jr, José Ranali
Affiliations

Cardiovascular effects of felypressin

Rodrigo Cecanho et al. Anesth Prog. 2006 Winter.

Abstract

Cardiovascular effects of felypressin (FEL) were studied in Wistar rats. Heart rate and mean arterial pressure measurements were taken in awake rats treated with vasopressin (AVP), FEL, or epinephrine (EPI). Each group received either an intravenous (IV) or an intracerebroventricular V1 receptor antagonist, saline, area postrema removal, or sham surgery. Analysis of variance and Student-Newman-Keuls (P < .05) were applied. Felypressin and AVP induced a pressor effect, and bradycardia was inhibited by IV V1 antagonist. Intracerebroventricular V1 antagonist and area postrema removal enhanced their pressor effects. Epinephrine induced a higher pressor effect and a similar bradycardia that was not affected by the treatments. It was concluded that FEL depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors. These effects are potentially less harmful to the cardiovascular system than the effects of EPI.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean and SEM of mean arterial pressure of the rats submitted to intravenous (IV) injection of 240 ng kg−1 of felypressin (FEL), 250 ng kg−1 of vasopressin (AVP), or 2 μg kg−1 of epinephrine (EPI) after IV injection of 0.9% NaCl, IV injection of 15 μg kg−1 of β-mercapto-β,β-cyclopentamethylenepropionyl-0 methyl-tyrosine, arginine vasopressin (β-MER), intracerebroventricular (ICV) injection of 100 ng of B-mer, or removal (APX) or sham removal (APS) of area postrema. Different letters mean a statistical difference (P < .05) between different treatments of the same group. * P < .05 versus EPI group.
Figure 2
Figure 2
Mean and SEM of heart rate of the rats submitted to intravenous (IV) injection of 240 ng kg−1 of felypressin (FEL), 250 ng kg−1 of vasopressin (AVP), or 2 μg kg−1 of epinephrine (EPI) after IV injection of 0.9% NaCl, IV injection of 15 μg kg−1 of β-mercapto-β,β-cyclopentamethylenepropionyl-0 methyl-tyrosine, arginine vasopressin (β-MER), intracerebroventricular (ICV) injection of 100 ng of B-MER, or removal (APX) or sham removal (APS) of area postrema. Different letters mean a statistical difference (P < .05) between different treatments of the same group.
See this image and copyright information in PMC

References

    1. Brahma AK, Pemberton CJ, Ayeko M, Morgan LH. Single medial injection peribulbar anaesthesia using prilocaine. Anaesthesia. 1994;49:1003–1005. - PubMed
    1. Coulthard P. Local anesthetic use among GDPs. Br Dent J. 2005;199:778.
    1. Jackson EK. Vasopressina e outros agentes que afetam a conservação renal de água. In: Goodman GA, editor. As Bases Farmacológicas da Terapêutica. 9th ed. Rio de Janeiro, Brazil: McGraw Hill; 1996. pp. 523–535.
    1. Meechan JG. The effects of dental local anesthetics on blood glucose concentration in healthy volunteers and in patients having third molar surgery. Br Dent J. 1991;170:373–376. - PubMed
    1. Meechan JG, Cole B, Welbury RR. The influence of two different dental local anesthetic solutions on the haemodynamic responses of children undergoing restorative dentistry: a randomized, single-blind, split-mouth study. Br Dent J. 2001;190:502–504. - PubMed