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. 2006 Nov;6(4):18-21.
doi: 10.17305/bjbms.2006.3112.

The role of pineal gland and exogenous melatonin on the irradiation stress response of suprarenal gland

Selma Alicelebić  1 , Zakira Mornjaković, Irfan Susko, Esad Cosović, Amira Beganović-Petrović
Affiliations

The role of pineal gland and exogenous melatonin on the irradiation stress response of suprarenal gland

Selma Alicelebić et al. Bosn J Basic Med Sci. 2006 Nov.

Abstract

Pineal gland has and antistressogenic role. Its main hormone, melatonin, has radio protective effect on endocrine and other dynamic tissues. In our previous study, we have shown that pinealectomy changes the behavior of suprarenal gland in totally irradiated rats. The aim of this study is to evaluate the effect of exogenous melatonin on suprarenal gland of rats with or without pineal gland. Four months after pinealectomy (experimental group) or shampinealectomy (control group), adult Wistar male rats were daily treated with 0,2 mg of melatonin intraperitoneally, during two weeks. Thereafter, all animals were totally irradiated with 8 Gy of Gamma rays produced from Cobalt 60. Animals who survived were sacrificed on the 17(th) post irradiation day. Qualitative and quantitative characteristics of the suprarenal gland were studied using histological methods. The results show that exogenous melatonin had protective role on suprarenal gland in totally irradiated rats and that those effects were more pronounced in the presence of pineal gland.

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Figures

FIGURE 1
FIGURE 1
Pinealectomized and melatonin treated irradiated rats. Azan, x 100
FIGURE 2
FIGURE 2
Shampinealectomized and melatonin treated irradiated rats. Azan, x 60.
See this image and copyright information in PMC

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