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. 2007 Jan;56(1):54-6.
doi: 10.1111/j.1600-0536.2007.00944.x.

Haptens, prohaptens and prehaptens, or electrophiles and proelectrophiles

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Haptens, prohaptens and prehaptens, or electrophiles and proelectrophiles

Aynur O Aptula et al. Contact Dermatitis. 2007 Jan.

Abstract

It is argued that the term 'hapten', and derived terms such as 'pro-hapten' and 'pre-hapten' are ambiguous and unnecessary. It is proposed that their use be abandoned. Instead, when considering the chemical basis of skin sensitization, it is preferable to classify compounds according to the chemical reaction mechanisms by which they can modify proteins.

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