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Review
. 2006 Dec;12(4):172-4.
doi: 10.1258/136218006779160517.

Controversies in the use of adjuvant trastuzumab (Herceptin)

Simon Chowdhury  1 , Lisa Pickering, Paul Ellis
Affiliations
Review

Controversies in the use of adjuvant trastuzumab (Herceptin)

Simon Chowdhury et al. J Br Menopause Soc. 2006 Dec.

Abstract

Over-expression of the human epidermal growth factor receptor 2 (HER2) protein, amplification of the HER2 gene or both occur in 15-25% of breast cancers and are associated with aggressive tumour behaviour. Trastuzumab (Herceptin), a humanized murine monoclonal antibody against the HER2 protein, has been shown to benefit patients with HER2-positive metastatic breast cancer when administered alone or in combination with chemotherapy. When to start therapy, the duration of treatment, adjuvant chemotherapy regimens and cardiotoxicity issues are examined.

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