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Review
. 2007 Feb;18(1):77-83.
doi: 10.1016/j.semcdb.2006.11.011. Epub 2006 Nov 24.

Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome

Huansheng Xu  1 , Antonio Baldini
Affiliations
Review

Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome

Huansheng Xu et al. Semin Cell Dev Biol. 2007 Feb.

Abstract

Mammalian heart development requires multiple genetic networks, only some of which are becoming known in all their complexity. Substantial new information has become available thanks to an expanding toolkit that offers more and more mouse gene manipulation options, and that is taking the mouse closer to more powerful invertebrate genetic models. We review examples of recent data with a cardiac-lineage-based view of heart development, especially outflow tract and right ventricle. The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration.

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Figures

Fig. 1
Fig. 1
The two cell lineages that contribute to the heart.
Fig. 2
Fig. 2
A putative genetic network operating in the second heart lineage. Dashed lines indicate the most speculative links.
See this image and copyright information in PMC

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