Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jul;91(7):958-61.
doi: 10.1136/bjo.2006.110387. Epub 2006 Dec 19.

Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium

Satoru Kase  1 , Shuji Takahashi, Izuru Sato, Katsuya Nakanishi, Kazuhiko Yoshida, Shigeaki Ohno
Affiliations

Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium

Satoru Kase et al. Br J Ophthalmol. 2007 Jul.

Abstract

Background: The pterygium is a growth onto the cornea of fibrovascular tissue that is continuous with the conjunctiva, whereas the mechanisms of cell proliferation in pterygium epithelium are unknown.

Aim: To analyse the histopathology and the expression of cell cycle-related molecules in pterygium tissues.

Methods: Seven pterygia were surgically removed using the bare-sclera procedure, and three normal bulbar conjunctivas were also obtained. Formalin-fixed, paraffin-wax-embedded tissues were analysed by immunohistochemistry with anti-p27(KIP1), cyclin D1 and Ki-67 antibodies.

Results: Conjunctival epithelium consisted of several layers of round cells with a few goblet cells. Nuclear immunoreactivity for p27(KIP1) was noted in many normal epithelial cells, where cyclin D1 and Ki-67-positive nuclei were intermingled. A variety of goblet cells were located in the superficial layer of the pterygium head as well as those of the body epithelia. Several pterygium epithelial cells were p27(KIP1) positive, whereas nuclear immunoreactivity for cyclin D1 and Ki-67 was detected in many epithelial cells. By contrast, immunoreactivity for p27(KIP1), cyclin D1 and Ki-67 was hardly detected in the pterygium stroma.

Conclusion: It is suggested that pterygium growth and development are associated with the proliferation of epithelium, which is possibly involved in the expression of cell cycle-related molecules.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Comment in

References

    1. Threlfall T J, English D R. Sun exposure and pterygium of the eye: a dose‐response curve. Am J Ophthalmol 1999128280–287. - PubMed
    1. Chan C M, Liu Y P, Tan D T. Ocular surface changes in pterygium. Cornea 20022138–42. - PubMed
    1. Solomon A, Grueterich M, Li D Q.et al Overexpression of insulin‐like growth factor‐binding protein‐2 in pterygium body fibroblasts. Invest Ophthalmol Vis Sci 200344573–580. - PubMed
    1. Kase S, Kitaichi N, Furudate N.et al Increased expression of mucinous glycoprotein KL‐6 in human pterygium. Br J Ophthalmol 2006901208–1209. - PMC - PubMed
    1. Sherr C J, Roberts J M. Inhibitors of mammalian G1 cyclin‐dependent kinases. Genes Dev 199591149–1163. - PubMed