Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jun 18;251(1):78-85.
doi: 10.1016/j.canlet.2006.11.006. Epub 2006 Dec 19.

Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer

Wei Huang  1 , Jie Zhong, Lin-Yun Wu, Li-Fen Yu, Xiang-Long Tian, Yi-Fan Zhang, Biao Li
Affiliations

Downregulation and CpG island hypermethylation of NES1/hK10 gene in the pathogenesis of human gastric cancer

Wei Huang et al. Cancer Lett. .

Abstract

The normal epithelial cell-specific-1 (NES1)/Kallikrein 10 gene is proposed to be a novel putative tumor suppressor gene in several malignant diseases. The role of NES1 gene in gastric cancer has not been fully understood. Our study revealed that CpG island hypermethylation plays an important role in the downregulation of NES1 mRNA expression in gastric cancer. In situ hybridization showed that loss or reduction of NES1 mRNA expression is associated with differentiation level during tumor progression suggesting that NES1 inactivation might contribute to the malignant progression of human gastric cancers.

PubMed Disclaimer

MeSH terms

LinkOut - more resources