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Review
. 2007 May;42(5):421-6.
doi: 10.1016/j.exger.2006.11.007. Epub 2006 Dec 19.

Dendritic cells in human aging

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Review

Dendritic cells in human aging

Anshu Agrawal et al. Exp Gerontol. 2007 May.

Abstract

Dendritic cells (DCs) play a critical role in linking innate and adaptive immunity. A role of DCs in immunosenescence and chronic inflammation associated with aging has not been investigated in detail. In this article, we will briefly review DCs biology and changes associated with human aging.

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References

    1. Akira S, Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004;4:499. - PubMed
    1. Ardeshna KM, Pizzey AR, Walker SJ, Devereux S, Khwaja A. The upregulation of CC chemokine receptor 7 and the increased migration of maturing dendritic cells to macrophage inflammatory protein 3beta and secondary lymphoid chemokine is mediated by the p38 stress-activated protein kinase pathway. Br J Haematol. 2002;119:826–829. - PubMed
    1. Bhushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I, Griffiths CE. Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Brit. J. Dermatol. 2002;146:32–40. - PubMed
    1. Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J. Leukoc. Biol. 2004;75:342–349. - PubMed
    1. Brunnsgaard H, Andersen-Ranberg K, Hjelmborg JB, Pedersen BK, Jeu B. Elevated tumor necrosis factor alpha and mortality in centenarians. Amer. J. Med. 2003;115:278–283. - PubMed

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