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. 1991 Oct;34(10):1313-8.
doi: 10.1002/art.1780341017.

Antibodies to retroviral proteins and reverse transcriptase activity in patients with essential cryoglobulinemia

A Perl  1 , P D Gorevic, J J Condemi, L Papsidero, B J Poiesz, G N Abraham
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Antibodies to retroviral proteins and reverse transcriptase activity in patients with essential cryoglobulinemia

A Perl et al. Arthritis Rheum. 1991 Oct.

Abstract

Human T cell lymphotropic virus type I (HTLV-I) gag and env protein-specific antibodies were identified in 6 of 13 patients with essential cryoglobulinemia (EC), by Western blot and radioimmunoprecipitation analysis. Supernatants of cells from 2 of the 5 EC patients tested showed reverse transcriptase activity. DNA sequences homologous to HTLV-I could not be detected by polymerase chain reaction, thus excluding the presence of prototype HTLV-I in each patient with EC. The data suggest that retroviral proteins distinct from but related to HTLV-I may be involved in the pathogenesis of EC in some patients.

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