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Comparative Study
. 2007 Jan;13(1):91-3.
doi: 10.1111/j.1469-0691.2006.01576.x.

The persistence of humoral and cellular immunities more than three decades after smallpox vaccination

S-H Kim  1 , S-G Yeo, K-H Park, J-W Bang, H-B Kim, N-J Kim, Y Jee, H Cho, M-D Oh, K-W Choe
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Free article
Comparative Study

The persistence of humoral and cellular immunities more than three decades after smallpox vaccination

S-H Kim et al. Clin Microbiol Infect. 2007 Jan.
Free article

Abstract

This study assessed the persistence of humoral (neutralising antibody titre to vaccinia virus) and cellular (immediate vaccinia-specific interferon (IFN)-gamma-producing T-cell) immunities to smallpox in a Korean population. Individuals who were vaccinated 25-60 years previously had higher neutralising antibody titres (geometric mean titre (GMT) 13.7; 95% CI 11.0-17.2) than vaccinia-naive individuals (GMT 6.7; 95% CI 5.5-8.0; p <0.001). However, there was no significant difference in cellular immunity between individuals vaccinated previously and vaccinia-naive individuals, and only 15% of the individuals vaccinated previously displayed an immediate IFN-gamma-producing effector-memory response in ELISPOT assays.

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