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Review
. 2006 Dec;77(6):485-638.
doi: 10.1002/bdrb.20087.

NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein

Karl K Rozman  1 , Jatinder Bhatia, Antonia M Calafat, Christina Chambers, Martine Culty, Ruth A Etzel, Jodi A Flaws, Deborah K Hansen, Patricia B Hoyer, Elizabeth H Jeffery, James S Kesner, Sue Marty, John A Thomas, David Umbach
Affiliations
Review

NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein

Karl K Rozman et al. Birth Defects Res B Dev Reprod Toxicol. 2006 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Structures of genistein and genistein glucosides.
Fig. 2
Fig. 2
Metabolism of genistin and genistein. Adapted from UK Committee on Toxicity (2003) and Joannou et al. (1995).
Fig. 3
Fig. 3
Estimated genistein intake in the dietary treatment study of You et al. (2002a).
Fig. 4
Fig. 4
Body weight of male rats treated on PND 1–5 with oral genistein 0–100 mg/kg bw/day. Drawn from data presented in Nagao et al. (2001). Error bars omitted for clarity. Pair-wise difference from control in 25 and 50 mg/kg bw/day groups at Weeks 9 and 18, in 50 mg/kg bw/day group at Weeks 5, 7, 9, and 18, and in 100 mg/kg bw/day group at all time points from PND 6 on.
Fig. 5
Fig. 5
Weight of female rats treated on PND 1–5 with oral genistein 0–100 mg/kg bw/day. Drawn from data presented in Nagao et al. (2001). Error bars omitted for clarity. Pair-wise difference from control in 25 and 50 mg/kg bw/day groups at Weeks 9 and 18, in 50 mg/kg bw/day group at Weeks 5, 7, and 9, and in 100 mg/kg bw/day group at all time points after PND 6.
See this image and copyright information in PMC

References

    1. Adachi T, Ono Y, Koh KB, Takashima K, Tainaka H, Matsuno Y, Nakagawa S, Todaka E, Sakurai K, Fukata H, Iguchi T, Komiyama M, Mori C. Long-term alteration of gene expression without morphological change in testis after neonatal exposure to genistein in mice: toxicogenomic analysis using cDNA microarray. Food Chem Toxicol. 2004;42:445–452. - PubMed
    1. Adeoya-Osiguwa SA, Markoulaki S, Pocock V, Milligan SR, Fraser LR. 17beta-Estradiol and environmental estrogens significantly affect mammalian sperm function. Hum Reprod. 2003;18:100–107. - PubMed
    1. Adlercreutz H. Phytooestrogens and cancer. Lancet Oncol. 2002;3:364–373. - PubMed
    1. Adlercreutz H, Fotsis T, Lampe J, Wahala K, Makela T, Brunow G, Hase T. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest Suppl. 1993a;215:5–18. - PubMed
    1. Adlercreutz H, Markkanen H, Watanabe S. Plasma Concentrations of PhytoOestrogens in Japanese Men. Lancet. 1993b;342:1209–1210. - PubMed