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. 2007 Apr;42(4):487-93.
doi: 10.1016/j.ejmech.2006.11.002. Epub 2006 Nov 18.

Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

Aihong Kim  1 , Joon Hee Hong
Affiliations

Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

Aihong Kim et al. Eur J Med Chem. 2007 Apr.

Abstract

A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 microg/mL, in AD-169).

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