Review
doi: 10.1016/j.molcel.2006.12.005.
To die or not to die: a HAT trick
Affiliations
- PMID: 17189182
- DOI: 10.1016/j.molcel.2006.12.005
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Review
To die or not to die: a HAT trick
Mol Cell.
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Free article
Abstract
In this issue of Molecular Cell, two manuscripts (Sykes et al., 2006) propose that the decision to undergo apoptosis upon DNA damage is mediated through acetylation of p53 within its DNA-binding domain by MYST histone acetyltransferases.
Comment on
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Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis.Mol Cell. 2006 Dec 28;24(6):827-39. doi: 10.1016/j.molcel.2006.11.021. Mol Cell. 2006. PMID: 17189186
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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.Mol Cell. 2006 Dec 28;24(6):841-51. doi: 10.1016/j.molcel.2006.11.026. Mol Cell. 2006. PMID: 17189187 Free PMC article.
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