Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2006 Dec 26;67(12):2233-5.
doi: 10.1212/01.wnl.0000249308.66959.43.

Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia

J Jankovic  1 , C Hunter, B Z Dolimbek, G S Dolimbek, C H Adler, A Brashear, C L Comella, M Gordon, D E Riley, K Sethi, C Singer, M Stacy, D Tarsy, M Z Atassi
Affiliations
Clinical Trial

Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia

J Jankovic et al. Neurology. .

Abstract

In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy.

PubMed Disclaimer

Publication types

LinkOut - more resources