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. 2006 Dec 31;47(6):787-92.
doi: 10.3349/ymj.2006.47.6.787.

Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population

Se Joo Kim  1 , Young Shin Kim, Chan-Hyung Kim, Hong Shick Lee
Affiliations

Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population

Se Joo Kim et al. Yonsei Med J. .

Abstract

Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.

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References

    1. Bouchard TJ., Jr Genes, environment, and personality. Science. 1994;264:1700–1701. - PubMed
    1. Cloninger CR. A systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry. 1987;44:573–588. - PubMed
    1. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem. 1995;65:1157–1165. - PubMed
    1. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blanie D, et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet. 1996;12:78–80. - PubMed
    1. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet. 1996;12:81–84. - PubMed

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