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. 2006 Oct;59(10):659-63.
doi: 10.1038/ja.2006.88.

Oxachelin, a novel iron chelator and antifungal agent from Streptomyces sp. GW9/1258

Bernd Sontag  1 , Martin Gerlitz, Thomas Paululat, Hans-Falk Rasser, Iris Grün-Wollny, Friedrich G Hansske
Affiliations

Oxachelin, a novel iron chelator and antifungal agent from Streptomyces sp. GW9/1258

Bernd Sontag et al. J Antibiot (Tokyo). 2006 Oct.

Abstract

During a screening campaign for new antimicrobial and antifungal secondary metabolites from several thousand actinomycetes, a novel compound, isolated by activity guided fractionation, was oxachelin (1) from the new Streptomyces sp. GW9/1258. Oxachelin shows strong antibiotic activities against several fungi and Gram(+) bacteria. Additionally, oxachelin is a strong complexing ligand for Fe3+ (siderophore), possibly making it useful e.g. for iron excess diseases.

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