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. 2006;30(1-2):223-6.
doi: 10.1385/JMN:30:1:223.

MuSK signaling at the neuromuscular junction

Qiang Wang  1 , Bin Zhang, Wen-Cheng Xiong, Lin Mei
Affiliations

MuSK signaling at the neuromuscular junction

Qiang Wang et al. J Mol Neurosci. 2006.

Abstract

The neuromuscular junction (NMJ) is a peripheral cholinergic synapse that conveys signals from motor neurons to muscle cells (Sanes and Lichtman, 1999; Sanes and Lichtman, 2001). The formation of the NMJ requires communication between motoneurons and muscle fibers. Three molecules are essential for NMJ formation: agrin, MuSK, and rapsyn. MuSK appears to be involved in every aspect of NMJ development and maintenance. The paper reviews agrin-MuSK cascades and its potential cross talk with Wnt signaling pathways.

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