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Comparative Study
. 2006 Jan;3(1):101-5.
doi: 10.1002/cbdv.200690000.

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han  1 , Ling Yang, Yu-Lin Wang, Chun-Feng Qiao, Jing-Zheng Song, Han-Dong Sun, Hong-Xi Xu
Affiliations
Comparative Study

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han et al. Chem Biodivers. 2006 Jan.

Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

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