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. 2007 Jan;71(1):70-3.

Terbutaline pharmacokinetics in cows: preliminary data

Melanie J Boileau  1 , Kevin E Washburn, Cyril R Clarke, Robert N Streeter, Lara K Maxwell
Affiliations

Terbutaline pharmacokinetics in cows: preliminary data

Melanie J Boileau et al. Can J Vet Res. 2007 Jan.

Abstract
in English, French

The objective of this study was to determine the serum pharmacokinetics of terbutaline in healthy cows. In the initial experiment, terbutaline was administered once as an intravenous (i.v.) bolus to 6 near-term pregnant beef cows within 24 h after parturition at a low but therapeutically relevant dose, 5 microg/kg. A 2nd experiment was conducted in the same cows with a higher dose, 0.5 mg/kg, but an otherwise similar experimental design. The serum concentration of terbutaline was determined by means of high-performance liquid chromatography with fluorescence detection in both experiments. After i.v. administration of 0.5 mg/kg, the mean peak serum concentration, residence time, and half-life were 708.22 (standard deviation 509.6) ng/mL, 6.75 (3.6) min, and 6.93 (2.4) min, respectively. The results indicate that terbutaline is rapidly eliminated from the bloodstream after i.v. administration in cattle, falling below the assay's limit of detection 30 min after administration.

L’objectif de cette étude était de déterminer la pharmacocinétique sérique de la terbutaline chez des vaches en santé. Dans l’expérience initiale, de la terbutaline a été administrée en une fois sous forme de bolus intraveineux (IV) à six vaches d’embouche à moins de 24 h après la parturition à un dosage faible mais adéquat pour un usage thérapeutique, soit 5 μg/kg. Une deuxième expérience a été effectuée chez les mêmes vaches en utilisant un design expérimental similaire mais en administrant une dose plus élevée, soit 0,5 mg/kg. La concentration sérique de terbutaline a été déterminée par chromatographie en phase liquide à haute performance avec détection par fluorescence dans les deux expériences. Après l’administration IV de 0,5 mg/kg, le pic moyen de la concentration sérique, le temps de résidence et la demi-vie étaient, respectivement, 708,22 (écart type de 509,6) ng/mL, 6,75 (3,6) min et 6,93 (2,4) min. Ces résultats indiquent que la terbutaline est rapidement éliminée de la circulation sanguine chez les vaches après administration IV, se retrouvant sous la limite de détection de l’épreuve 30 min après l’administration.

(Traduit par Docteur Serge Messier)

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Figures

Figure 1
Figure 1
Mean serum concentration versus time after administration of terbutaline as a single intravenous bolus of 0.5 mg/kg to 6 cows.
Figure 2
Figure 2
Semilogarithmic plot of the mean serum concentration of terbutaline, illustrating the distribution and elimination phases. Ln Cp — natural logarithm of the plasma concentration.
See this image and copyright information in PMC

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