Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan;71(1):74-6.

Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats

Pedro Marín  1 , Carlos M Cárceles, Elisa Escudero, Emilio Fernández-Varón
Affiliations

Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats

Pedro Marín et al. Can J Vet Res. 2007 Jan.

Abstract
in English, French

The pharmacokinetic behavior of ibafloxacin was studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of ibafloxacin were determined by high-performance liquid chromatography with fluorescence detection. The data for concentration versus time could best be described by a 2-compartment model. The mean plasma ibafloxacin clearance (and standard error) was 1.05 (0.10) L/h x kg. The mean steady-state volume of distribution was 1.65 (0.42) L/kg. The mean elimination half-life was 3.76 (0.30) h. Ibafloxacin penetration from the blood to the milk was poor. The ratio between the areas under the concentration-time curve of milk and plasma was 0.20 (0.01), indicating scant penetration of ibafloxacin into the milk.

Les propriétés pharmacocinétiques de l’ibafloxacine ont été étudiées après administration intraveineuse d’une dose unique de 15 mg/kg à six chèvres en santé en lactation. Les concentrations plasmatiques d’ibafloxacine ont été mesurées par chromatographie en phase liquide à haute performance avec détection par fluorescence. Les données de la concentration en fonction du temps peuvent être le mieux décrites par un modèle à 2 compartiments. La clairance plasmatique moyenne d’ibafloxacine (et l’erreur type) était 1,05 (0,10) L/h·kg. Le volume moyen de distribution à l’équilibre dynamique était 1,65 (0,42) L/kg. La demi-vie moyenne d’élimination était 3,76 (0,30) h. La pénétration d’ibafloxacine du sang vers le lait était faible. Le ratio entre les surfaces sous la courbe de la relation concentration–temps du sang et du plasma était 0,20 (0,01), indiquant une pénétration peu marquée de l’ibafloxacine dans le lait.

(Traduit par Docteur Serge Messier)

PubMed Disclaimer

Figures

Figure 1
Figure 1
Semilogarithmic plot of the mean concentrations (and standard errors) of ibafloxacin in plasma (—•—) and milk (—○—) of 6 healthy lactating goats after a single intravenous dose of 15 mg/kg body weight.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Coulet M, van Borssum Waalkes M, Cox P, Lohuis J. In vitro and in vivo pharmacodynamic properties of the fluoroquinolone ibafloxacin. J Vet Pharmacol Ther. 2002;25:401–411. - PubMed
    1. Walker RD. Fluoroquinolones. In: Prescott JF, Baggot JD, Walker RD, eds. Antimicrobial Therapy in Veterinary Medicine. Ames, Iowa: Iowa State University Press, 2000:315–338.
    1. Fernández-Varón E, Villamayor L, Escudero E, Espuny A, Cárceles CM. Pharmacokinetics and milk penetration of moxifloxacin after intravenous and subcutaneous administration to lactating goats. Vet J. 2006;172:302–307. - PubMed
    1. Abo El-Sooud K. Influence of albendazole on the disposition kinetics and milk antimicrobial equivalent activity of enrofloxacin in lactating goats. Pharmacol Res. 2003;48:389–395. - PubMed
    1. Abd El-Aty AM, Goudah A. Some pharmacokinetic parameters of pefloxacin in lactating goats. Vet Res Commun. 2002;26:553–561. - PubMed

LinkOut - more resources