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Case Reports
. 2006 Dec;3(12):e475.
doi: 10.1371/journal.pmed.0030475.

Hypogammaglobulinemia with facial edema

Adina Kay Knight  1 , Lloyd Mayer, Andrew G Franks Jr, Charlotte Cunningham-Rundles
Affiliations
Case Reports

Hypogammaglobulinemia with facial edema

Adina Kay Knight et al. PLoS Med. 2006 Dec.

Abstract

Knight and colleagues discuss the diagnosis and management of a 35-year-old man with a past history of recurrent cellulitis and otitis media and a two-year history of facial swelling.

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Conflict of interest statement

Competing Interests: Adina Kay Knight has received travel grants to attend meetings of the American College of Allergy, Asthma, and Immunology, the American Academy of Allergy, Asthma, and Immunology, the Clinical Immunology Society, the International Congress of Mucosal Immunology, and the Federation of Clinical Immunology Societies. Two years of fellowship were supported by the American Academy of Allergy, Asthma, and Immunology Clinical Fellowship Award. Charlotte Cunningham-Rundles has received research grants from the United States National Institutes of Health and USIDNet, an offshoot of the Immune Deficiency Foundation. She is a member of the US Food and Drug Administration Bodd Safety Advisory Board and National Institutes of Health review committees and of the Immune Deficiency Foundation and the Jeffrey Modell Foundation. LM and AGF declare that they have no competing interests.

Figures

Figure 1
Figure 1. Response to Oral Budesonide
Stool protein loss, as measured by alpha-1 antitrypsin, decreased with oral locally active rapidly metabolized steroids and increased when the steroids were stopped, suggesting a steroid responsive gastrointestinal inflammation as the underlying cause of the protein loss (including loss of immunoglobulins).
See this image and copyright information in PMC

References

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    1. Knight AK, Cunningham-Rundles C. Oxcarbazepine-induced immunoglobulin deficiency. Clin Diagn Lab Immunol. 2005;12:560–561. - PMC - PubMed
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    1. Ballow M. Primary immunodeficiency disorders: Antibody deficiency. J Allergy Clin Immunol. 2002;109:581–591. - PubMed
    1. Busse PJ, Razvi S, Cunningham-Rundles C. Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J Allergy Clin Immunol. 2002;109:1001–1004. - PubMed

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