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Review
. 2007 Aug;1773(8):1248-55.
doi: 10.1016/j.bbamcr.2006.11.009. Epub 2006 Nov 16.

Clinical experience of MEK inhibitors in cancer therapy

Ding Wang  1 , Scott A Boerner, James D Winkler, Patricia M LoRusso
Affiliations
Free article
Review

Clinical experience of MEK inhibitors in cancer therapy

Ding Wang et al. Biochim Biophys Acta. 2007 Aug.
Free article

Abstract

Finding new therapies to assist in the treatment of cancer is a major challenge of clinical research. Small molecules that inhibit different molecular targets at the different levels of the MAPK pathway have been developed. Several MEK inhibitors have been examined in early-phase clinical trials and the current state of clinical results using these therapies is presented here.

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