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Review
. 2007:64:49, 51-77.
doi: 10.1007/978-3-7643-7567-6_3.

Chemical genetics: an evolving toolbox for target identification and lead optimization

Helena I Boshoff  1 , Cynthia S Dowd
Affiliations
Review

Chemical genetics: an evolving toolbox for target identification and lead optimization

Helena I Boshoff et al. Prog Drug Res. 2007.

Abstract

Chemical genetics combines chemistry with biology as a means of exploring the function of unknown proteins or identifying the proteins responsible for a particular phenotype. Chemical genetics is thus a valuable tool in the identification of novel drug targets. This chapter describes the application of chemical genetics in traditional and systems-based approaches to drug target discovery and the tools/approaches that appear most promising for guiding future pharmaceutical development.

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