[Optimization of hepatoprotective therapy of viral hepatitis with consideration of neuromediatory link of pathogenesis]

Abstract

Aim: To study therapeutic efficacy of hepatoprotective modalities on the experimental hepatitis model and in patients with parenteral hepatitis B and C regarding neurogenic amines and their coefficients.

Material and methods: 38 hepatoprotectors were screened for the highest activity in 1000 white rats with toxic hepatitis. Blood catecholamines (CA), histamine (H), serotonin (S), 11-oxycorticosteroids (11-OCS) were studied in 100 patients with acute hepatitis B and C.

Results: The recommended hepatoprotectors optimized treatment of hepatitis, led to rapid correction of abdominal and dyspeptic syndromes, normalization of bilirubin, alkaline phosphatase, cytolysis enzymes levels, improvement of neuromediatory balance. Six-month follow-up demonstrated improvement of biochemical indices in patients given hepatoprotectors with a confirmed action.

Conclusion: Hepatoprotectors are necessary in pathogenetic treatment of acute hepatitis B and C.