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. 2006;78(11):70-6.

[Catalytic autoantibodies--a new molecular instrument in cardiology and ophthalmology]

[Article in Russian]
K A Mal'tsev, A N Khitrov, O Iu Vvedenskaia, N A Ponomarenko, M A Isaeva, M V Klimova, E B Tret'iak, Z S Shogenov, Z S Alekberova, S V Gabibov, S V Suchkov
  • PMID: 17195532

[Catalytic autoantibodies--a new molecular instrument in cardiology and ophthalmology]

[Article in Russian]
K A Mal'tsev et al. Ter Arkh. 2006.

Abstract

Aim: To develop a conceptual model of using catalytic autoantibodies as diagnostic and monitoring tools in organ-specific autoimmune disorders.

Material and methods: A total of 99 patients (56 males and 43 females aged 21-52 years) with autoimmune myocarditis (AM) and 198 patients (77 males and 121 females aged 8-79 years) with autoimmune uveitis (A U) participated in the study. AM patients were examined for anticardiomyosin and anti-DNA autoantibodies (ACM, ADNAab), AU patients - for autoantibodies to S-antigen, IRBP, redopsin, phosphocine, autoDNA.

Results: AM patients had double level of DNA-binding autoantibodies. In 1/3 of them there was hydrolysing DNA and cytotoxic activity. In AU patients maximal titers were in Behcet's disease, sympathic ophthalmia, generalized uveitis and viral uveitis.

Conclusion: Autoantibodies with different specificity and function including DNA-abzymes can be additional diagnostic and prognostic markers.

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