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. 2007 Mar 1;17(5):1200-5.
doi: 10.1016/j.bmcl.2006.12.021. Epub 2006 Dec 12.

Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists

Adrian Hall  1 , Stephen Atkinson, Susan H Brown, Iain P Chessell, Anita Chowdhury, Gerard M P Giblin, Paul Goldsmith, Mark P Healy, Karamjit S Jandu, Matthew R Johnson, Anton D Michel, Alan Naylor, Jennifer A Sweeting
Affiliations

Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists

Adrian Hall et al. Bioorg Med Chem Lett. .

Abstract

Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.

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