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Review
. 2007 Jan 4;53(1):1-4.
doi: 10.1016/j.neuron.2006.12.018.

High affinity not in the vicinity?

Philip A Barker  1
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Free article
Review

High affinity not in the vicinity?

Philip A Barker. Neuron. .
Free article

Abstract

Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure of the full TrkA ectodomain complexed to NGF and examine the possibility of a ternary p75NTR-NGF-TrkA complex.

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