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Review
. 2007 Mar;184(1-2):37-44.
doi: 10.1016/j.jneuroim.2006.11.015. Epub 2006 Dec 28.

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

Lisa K Peterson  1 , Robert S Fujinami
Affiliations
Review

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

Lisa K Peterson et al. J Neuroimmunol. 2007 Mar.

Abstract

Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is generally accepted as the main determinant of permanent clinical disability. However, the role of axonal loss early in disease or during relapsing-remitting disease is still under investigation, as are the interactions and interdependency between inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of MS.

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References

    1. Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol. Today. 2000;21:141–147. - PubMed
    1. Babbé H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schröder R, Deckert M, Schmidt S, Ravid R, Rajewsky K. Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 2000;192:393–404. - PMC - PubMed
    1. Bechtold DA, Kapoor R, Smith KJ. Axonal protection using flecainide in experimental autoimmune encephalomyelitis. Ann. Neurol. 2004;55:607–616. - PubMed
    1. Bezzi P, Volterra A. A neuron-glia signalling network in the active brain. Curr. Opin. Neurobiol. 2001;11:387–394. - PubMed
    1. Bjartmar C, Trapp BD. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr. Opin. Neurol. 2001;14:271–278. - PubMed

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