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Multicenter Study
. 2007 Jan 11;21(2):193-7.
doi: 10.1097/QAD.0b013e3280118a0d.

The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals

Matthew S Freiberg  1 , Debbie M Cheng, Kevin L Kraemer, Richard Saitz, Lewis H Kuller, Jeffrey H Samet
Affiliations
Multicenter Study

The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals

Matthew S Freiberg et al. AIDS. .

Abstract

Objective: To examine the association between hepatitis C and prevalent cardiovascular disease (CVD) among HIV-infected individuals.

Design: A cross-sectional analysis of data from the HIV-Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort, a prospective cohort of HIV-infected individuals with current or past alcohol problems.

Methods: We analysed health questionnaire and laboratory data from 395 HIV-infected individuals (50.1% co-infected with hepatitis C) using logistic regression to estimate the odds ratio (OR) for the prevalence of CVD among those co-infected with hepatitis C and HIV compared with those infected with HIV alone.

Results: The prevalence of CVD was higher among those co-infected with hepatitis C compared with those with HIV alone (11.1 versus 2.5%, respectively). After adjusting for age, the OR for the prevalence of CVD was significantly higher among those with hepatitis C co-infection (adjusted OR 4.65, 95% confidence interval 1.70-12.71). The relationship between hepatitis C and CVD persisted when adjusting for age and other sociodemographic characteristics, substance use, and cardiovascular risk factors in separate regression models.

Conclusion: Co-infection with hepatitis C among a cohort of HIV-infected individuals was associated with a higher age-adjusted odds for the prevalence of CVD. These data suggest that hepatitis C infection may be associated with an increased risk of CVD among those co-infected with HIV.

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