Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jan;12(1-2):54-61.
doi: 10.1016/j.drudis.2006.10.013. Epub 2006 Nov 13.

Blood-brain barrier delivery

William M Pardridge  1
Affiliations
Review

Blood-brain barrier delivery

William M Pardridge. Drug Discov Today. 2007 Jan.

Abstract

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this barrier. Therefore, brain drug development programs of the future need to be re-configured so that drugs are formulated to enable transport into the brain via endogenous BBB transporters.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources