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. 2007 Jan 2;68(1):62-4.
doi: 10.1212/01.wnl.0000250330.44291.54.

Cognitive prognosis of patients with tuberous sclerosis complex

Elisabeth B Winterkorn  1 , Margaret B Pulsifer, Elizabeth A Thiele
Affiliations

Cognitive prognosis of patients with tuberous sclerosis complex

Elisabeth B Winterkorn et al. Neurology. .

Abstract

To assess cognitive outcome in patients with tuberous sclerosis complex (TSC) and identify predictive risk factors, we reviewed records of 107 patients who underwent comprehensive neuropsychiatric evaluation. Fifty-seven percent of patients with TSC had normal-range IQ/developmental quotient (DQ). Cognitive outcome was strongly associated with refractory seizures and TSC2 mutation. In TSC, IQ/DQ is bimodally distributed, and more than half of individuals are in the normal range.

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