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. 2007 Jan;97(1):11-4.

Alternatively spliced human tissue factor (asHTF) is not pro-coagulant

Petra Censarek  1 , Anett Bobbe, Maria Grandoch, Karsten Schrör, Artur-Aron Weber
Affiliations
  • PMID: 17200764

Alternatively spliced human tissue factor (asHTF) is not pro-coagulant

Petra Censarek et al. Thromb Haemost. 2007 Jan.

Abstract

It has been proposed that alternatively-spliced human tissue factor (asHTF) is pro-coagulant. We have evaluated the function of asHTF in a mammalian expression system. Full-length human tissue factor (HTF) and asHTF were cloned from smooth muscle cells and over-expressed in HEK293 cells. As expected, a marked pro-coagulant activity (FX activation, thrombin generation) was observed on the surface, in lysates, and on microparticles from HTF transfected cells. In contrast, no pro-coagulant activity of asHTF was observed.

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