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. 1975 Oct;8(4):474-8.
doi: 10.1128/AAC.8.4.474.

Efficacy of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters

L B Allen, J H Huffman, G R Revankar, R L Tolman, L N Simon, R K Robins, R W Sidwell

Efficacy of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters

L B Allen et al. Antimicrob Agents Chemother. 1975 Oct.

Abstract

Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of approximately 60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.

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References

    1. J Med Chem. 1975 Jul;18(7):721-6 - PubMed
    1. Cornell Vet. 1956 Jan;46(1):68-82 - PubMed
    1. Am J Pathol. 1957 Jul-Aug;33(4):709-27 - PubMed
    1. Antimicrob Agents Chemother. 1972 Feb;1(2):143-7 - PubMed
    1. Geriatrics. 1973 Apr;28(4):100-3 - PubMed

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