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. 2007 Jan;35(Database issue):D269-70.
doi: 10.1093/nar/gkl891.

REBASE--enzymes and genes for DNA restriction and modification

Richard J Roberts  1 , Tamas Vincze, Janos Posfai, Dana Macelis
Affiliations

REBASE--enzymes and genes for DNA restriction and modification

Richard J Roberts et al. Nucleic Acids Res. 2007 Jan.

Abstract

REBASE is a comprehensive database of information about restriction enzymes, DNA methyltransferases and related proteins involved in the biological process of restriction-modification. It contains fully referenced information about recognition and cleavage sites, isoschizomers, neoschizomers, commercial availability, methylation sensitivity, crystal and sequence data. Experimentally characterized homing endonucleases are also included. All newly sequenced genomes are analyzed for the presence of putative restriction systems and these data are included within the REBASE. The contents or REBASE may be browsed from the web (http://rebase.neb.com/rebase/rebase.ftp.html) and selected compilations can be downloaded by ftp (ftp.neb.com). Additionally, monthly updates can be requested via email.

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Figures

Figure 1
Figure 1
The distribution in REBASE of the components of the four Types of restriction systems is shown. Red, restriction enzyme genes; blue, methyltransferase genes; and yellow, specificity subunits. Full colors indicate genes whose products have been biochemically characterized, whereas shaded areas represent inferred function based on bioinformatic analysis of DNA sequences. The pop-out slices (with numbers in parentheses) indicate those genes where sequence is available for biochemically characterized enzymes. The adjacent numbers represent those for which only biochemical evidence is available.
See this image and copyright information in PMC

References

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